Sirtuins are a family of proteins often called the "longevity genes." They've been the subject of numerous scientific studies for their role in promoting health and longevity.
Genetic variants in sirtuin genes, specifically SIRT1, SIRT3, and SIRT6, have been linked with lifespan and aging-related diseases in several populations.
The Link Between Sirtuins and Longevity
In humans, variants of certain sirtuin genes like SIRT1, SIRT3 and SIRT6 have been associated with lifespan and age-related diseases. One 2020 study of Italian centenarians revealed a SIRT6 gene variant tied to a longer life. Another study in a Chinese population linked SIRT3 variants to 1.3 year increased lifespan on average for the 589 women possessing one SIRT3 variant genotype.
By regulating inflammation, metabolism, stress response and even gene activity, sirtuins help maintain biological balance. This contributes to their longevity effects. As we age, cellular processes like DNA repair slow while inflammation increases - things sirtuins help control. Boosting sirtuins may aid healthy aging.
Increasing Sirtuin Activity
The activity level of sirtuins relies partially on available NAD+, an essential cellular coenzyme that declines with age. Researchers are exploring compounds that boost NAD+ as a way to enhance sirtuin function. One candidate is NMN, a precursor that converts to NAD+ in the body.
Lifestyle changes can also stimulate sirtuins. Calorie restriction activates sirtuins, increasing lifespan in lab models. Regular exercise also elevates NAD+ to provide more fuel for sirtuins. While early evidence suggested the compound resveratrol may stimulate sirtuins, results from human trials are still mixed regarding efficacy and required dosing.
The Future of Longevity Research
We've only scratched the surface of fully understanding sirtuins' longevity impacts. Sirtuins provide clues, but human aging involves complex interactions between genetics, lifestyle, and environment. Ongoing advances in genetics offer hope of extending health span by delaying age-related chronic disease.
The quest for longevity has deep roots in human history. And while we don't expect a magic anti-aging breakthrough, unraveling the biology of aging - including the sirtuin story that originated in yeast - puts that goal within science's reach.
Some of the phrases in this post are adapted from various longevity researchers/scientist incl. David A. Sinclair
How can IMAET help!
1) IMAET can upregulate/stimulate the genes of the mitochondria by resonating with their frequency.
Go to the Allergens panel and type into search bar: sirtuins, read explanation, and if a session is desired set timer to 15 - 20 minutes, click on quick cycle and start feedback. Sirtuins interrelate with AMPK and NAD+ genes. All are genes of the mitochondria. You may be able to combine some of these ancient genes in a feedback.
Genes are the workhorses of our metabolism (which includes the immune system, detoxification), change their epigenetic expression (function) with bioenergetic communication.
Bonus: Try vitality / energy stimulant from the Frequency Specific panel:
I wish you Healthy Longevity.