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GSTP1 Gene And It's Role In Glutathione

You will find GSTP1 on the imaet software in the Allergen Profile.

The GSTP1 gene is involved in the production of an enzyme called glutathione S-transferase pi 1, which plays a crucial role in the detoxification of harmful substances in the body. The rs1138272 variant is a specific single nucleotide polymorphism (SNP) or genetic variation within the GSTP1 gene. The rs1138272 SNP involves a change in a single DNA building block (nucleotide) at position 313 in the GSTP1 gene. It results in a substitution of amino acids within the protein sequence, specifically an isoleucine (I) being replaced by a valine (V) residue at position 105 in the enzyme.

This particular SNP has been studied extensively in relation to various diseases and conditions. One of the most well-known associations is its involvement in cancer susceptibility. The variant has been implicated in increasing the risk of developing certain types of cancers, including lung, prostate, and colorectal cancer. The altered enzyme function may affect the body's ability to eliminate carcinogens and protect against DNA damage, leading to an increased susceptibility to these cancers.

Regarding cancer susceptibility, the rs1695 variant has been associated with an increased risk of certain cancers, including lung, bladder, and head and neck cancers. The altered enzyme activity may impair the body's ability to eliminate carcinogens and protect against DNA damage, contributing to a higher cancer risk.

This SNP has been extensively studied, particularly in the context of cancer susceptibility and drug response. The rs1695 variant has been associated with altered enzyme activity and may impact an individual's ability to detoxify certain substances effectively. Several studies have investigated its role in cancer development and treatment outcomes.

GSTP1 known for its ability to catalyze the conjugation of the reduced form of glutathione (GSH) to exogenous and endogenous hydrophobic electrophiles for the purpose of detoxification. It regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Modulation of Nuclear Factor-κB (NF-κB) Signaling: NF-κB is a transcription factor that plays a crucial role in the regulation of immune and inflammatory responses. GSTP1 has been shown to inhibit NF-κB activation and signaling pathways. By blocking NF-κB, GSTP1 can downregulate the expression of pro-inflammatory genes, such as cytokines (e.g., tumor necrosis factor-alpha, interleukin-6) and adhesion molecules, thereby reducing the overall inflammatory response.

Detoxification of Reactive Oxygen Species (ROS): GSTP1 is involved in the detoxification and elimination of reactive oxygen species, which are generated during inflammation and can contribute to tissue damage. By neutralizing ROS, GSTP1 helps to attenuate oxidative stress and limit inflammation-associated tissue injury.

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