Get to know your Genes - FOXO3

The FOXO3 gene is associated with longevity for several reasons. In flies and worms making

more of this gene all of the time, it can extend their lifespan by 100%: a worm that would've

only lived 15 days would instead live to ~30 days. In mice, having more of this gene can

extend their lifespan by 30% and humans with a polymorphism that makes more of foxo3 is

associated with being a centenarian (that is, living to be at least 100 years old). The reason

why having more FOXO3 is associated with longevity is because it turns on a whole host of genes that are involved in stress resistance making you more resilient to the damage that occurs everyday from just living (including normal metabolism and immune function). It turns on many different antioxidant genes, DNA repair genes that repair damage to your DNA, genes that kill cancer cells, genes that prevent proteins from aggregating, and more. FOXO3 is awesome.

Not all SNPs are negative. Some are beneficial. It's part of the adaptability (to the environment) of our genes and part of evolution itself.

The following polymorphisms are associated with the FOXO3 gene:

● rs2802292 (G;G)

This polymorphism is associated with between 1.5 to 2.7 times increased likelihood of

living to be a centenarian.

● rs2802292 (G;T)

This polymorphism is associated with between 1.5 to 2 times increased likelihood of

living to be a centenarian.

FOXO3 has been in the imaet database for 10 years, the metioned variants are not present. I am contemplating developing those frequencies, as longevity has become rather fashionable. Life is good.

So, anytime you notice FOXO3 at the bottom of a BioScan result, don't hesitate to put it into the Custom Feedback basket. And, there is nothing wrong with simply searching for this gene and running a feedback on it. If more ambitious and adventurous, imprint the FOXO3 frequency on a wearable, for example our bracelets. In my experience, these type of longevity frequencies are best worn at night (meaning during sleep). 100 is the new 30.

Author: Dr. Bernard Straile, DC