Biohacking the Genome - FOXP3 gene

Fred Ramsdell - Shimon Sakaguchi - Mary E Brunkow

The Nobel Price in Medicine for 2025 was awarded to a team of scientists who identified a class of cells, regulatory T cells (TRegs), and the genes that control them. In doing so, they answered puzzling biological questions: How does the immune system know to avoid attacking the body’s own healthy cells? And if by mistake some immune system cells fail to get the message, how are those cells stopped from wreaking havoc? This is the fundamental conundrum with auto-immune conditions, where the immune system "attacks the body's own tissues".

After years of arduous work, the researchers found the gene, called FOXP3, who makes and controls TReg cells. Without FOXP3, regulatory T cells do not form. Without a functioning FOXP3 gene, the body does not make T cells that tell other T cells that can attack the body’s cells not to respond.

“This is a great recognition of the fundamental importance of distinguishing self from non-self,” said John Wherry, director of the Colton Center for Autoimmunity at the University of Pennsylvania.

“The holy grail has been to be able to manipulate and control immunity versus tolerance," Dr. Maus said. “The work of these laureates unlocked the tolerance side of this equation.”

The FOXP3 gene itself was discovered more than 25 years ago. I had been studying this gene for a while and it is in the Biofield panel of the latest imaet software version 12.1. Coincidentally the Nobel Prize committee thought it was worth that recognition for these scientists to figure out the function of this important gene.

For us imaet practitioners, upregulating the FOXP3 gene in many auto-immune conditions sounds like a good idea. You will find it on the Biofield panel and on the Allergens panel.

Myself I have only worked with this gene in the clinic for a couple of months and I don't have any good case studies to present yet. Stay tuned and let me know your experiences. Most conveniently you would find the FOXP3 gene at the bottom of the BioScan. However, one can also search for it on either panel and use Test Single Item to determine lower than ideal function,anything below 50.

One can also make an executive decision and say, this patient's conditions warrants FOXP3 to function at the highest potential possible and simply put it in a feedback; together with a layer of pathogens, by itself, even imprint and wear it. There are so many effective ways to improve genetic function (epigenetics).

The narrative of the FOXP3 gene on the Biofield panels states: "The FOXP3 gene acts as a master regulator for the development and function of regulatory T cells (Tregs), which are crucial for immune system control. It can both activate and repress genes involved in immune function. It activates genes like CTLA4 and IL2RA while repressing others like IL2 and IFNG. It is a transcription factor that helps suppress excessive immune responses, preventing autoimmune diseases. While essential for maintaining tolerance to the body's own tissues, a lack of functional FOXP3 can lead to severe autoimmune disorders like IPEX syndrome. It is found primarily in an immune system gland called the thymus, where these regulatory T cells are produced."

Let's keep exploring bioenergetic regulation of Immune Function and counteract overreliance on vaccines as well as repair some of the vaccine injuries causing auto-immune conditions.

Author: Dr. Bernard Straile